Sylvie Garneau-Tsodikova Selected Research

Kanamycin

11/2022	Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity.
1/2018	Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.
1/2016	Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.
11/2013	Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase Eis.
4/2013	Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
6/2012	Aminoglycoside multiacetylating activity of the enhanced intracellular survival protein from Mycobacterium smegmatis and its inhibition.
6/2011	Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.

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Sylvie Garneau-Tsodikova Research Topics

Disease

10	Infections 10/2023 - 06/2011
10	Tuberculosis (Tuberculoses) 01/2023 - 06/2012
6	Bacterial Infections (Bacterial Infection) 11/2021 - 01/2010
5	Mycoses (Diseases, Fungus) 10/2019 - 11/2015
4	Alzheimer Disease (Alzheimer's Disease) 12/2019 - 09/2015
3	Plague (Bubonic Plague) 10/2023 - 01/2017
3	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 12/2016 - 01/2014
2	Hemolysis 12/2020 - 02/2019
2	Critical Illness (Critically Ill) 01/2016 - 11/2015
2	Invasive Fungal Infections 01/2016 - 11/2015
2	Extensively Drug-Resistant Tuberculosis 04/2013 - 06/2011
1	Asthma (Bronchial Asthma) 01/2023
1	Neoplasm Metastasis (Metastasis) 01/2023
1	Ovarian Neoplasms (Ovarian Cancer) 01/2023
1	Neoplasms (Cancer) 01/2023
1	Persistent Infection 11/2021
1	Periodontal Diseases (Periodontal Disease) 05/2021
1	Gingivitis 05/2021
1	Periodontitis 05/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Lung Injury 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Brain Diseases (Brain Disorder) 12/2019
1	Starvation 01/2018
1	Deafness (Deaf Mutism) 10/2017
1	Invasive Candidiasis 06/2017
1	Bipolar Disorder (Manic Depressive Psychosis) 12/2016
1	Brain Ischemia (Cerebral Ischemia) 12/2016
1	Noise-Induced Hearing Loss (Acoustic Trauma) 12/2016
1	Gram-Positive Bacterial Infections 01/2016
1	Ototoxicity 01/2016
1	HIV Infections (HIV Infection) 01/2016
1	Candidiasis (Moniliasis) 11/2015
1	Glioma (Gliomas) 03/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 05/2010
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2008
1	Dehydration (Water Stress) 10/2006

Drug/Important Bio-Agent (IBA)

18	AminoglycosidesIBA 01/2023 - 01/2010
12	Anti-Bacterial Agents (Antibiotics)IBA 03/2023 - 01/2010
7	Kanamycin FDA Link 11/2022 - 06/2011
6	AcetyltransferasesIBA 11/2022 - 06/2011
5	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2012
3	ZincIBA 10/2023 - 01/2017
3	EnzymesIBA 10/2019 - 07/2013
3	AzolesIBA 10/2017 - 11/2015
2	IronIBA 10/2023 - 11/2021
2	yersiniabactinIBA 10/2023 - 11/2021
2	Antifungal AgentsIBA 02/2019 - 10/2017
1	SolutionsIBA 03/2023
1	Sulfhydryl Compounds (Thiols)IBA 01/2023
1	IsomerasesIBA 01/2023
1	Tumor Biomarkers (Tumor Markers)IBA 01/2023
1	zafirlukast (Accolate)FDA LinkGeneric 01/2023
1	endoplasmic reticulum glycoprotein p72IBA 01/2023
1	ManganeseIBA 11/2021
1	SiderophoresIBA 11/2021
1	Trace Elements (Biometals)IBA 11/2021
1	AlginatesIBA 11/2021
1	(2-boronoethyl)-cysteineIBA 01/2021
1	ArginaseIBA 01/2021
1	GoldIBA 12/2020
1	Voriconazole (Vfend)FDA LinkGeneric 02/2019
1	ButyrylcholinesteraseIBA 12/2018
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2018
1	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2018
1	AcetylcholinesteraseIBA 12/2018
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	Antipsychotic Agents (Antipsychotics)IBA 10/2017
1	bromperidol (Impromen)IBA 10/2017
1	12S ribosomal RNAIBA 10/2017
1	Fluconazole (Zonal)FDA LinkGeneric 06/2017
1	ebselenIBA 12/2016
1	Gentamicins (Gentamicin)FDA LinkGeneric 10/2016
1	Tobramycin (Nebcin)FDA LinkGeneric 10/2016
1	Amikacin (A.M.K)FDA LinkGeneric 10/2016
1	Amyloid (Amyloid Fibrils)IBA 02/2016
1	ChalconesIBA 02/2016
1	LigandsIBA 02/2016
1	Therapeutic UsesIBA 01/2016
1	Streptomycin (Streptomycin Sulfate)FDA Link 01/2016
1	posaconazole FDA Link 12/2015
1	rheinIBA 03/2015
1	Lysine (L-Lysine)FDA Link 04/2013
1	Protein Kinase InhibitorsIBA 01/2008
1	BuffersIBA 10/2006

Therapy/Procedure

7	Therapeutics 01/2023 - 09/2015
2	Drug Therapy (Chemotherapy) 10/2019 - 01/2016
1	Organ Transplantation 01/2016
1	Intranasal Administration 03/2015